ANAPC4 and SEPSECS

Data Source:
BioGRID (affinity chromatography technology)

		ANAPC4	SEPSECS
Description		anaphase promoting complex subunit 4	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Periphery	Nucleus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Phosphatase Binding	TRNA Binding Protein Binding Transferase Activity, Transferring Selenium-containing Groups
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Selenocysteine Incorporation Selenocysteine Metabolic Process Selenocysteinyl-tRNA(Sec) Biosynthetic Process
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Selenocysteine synthesis
Drugs			Pyridoxal phosphate
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Body size at age 10 ( 32376654) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Logical memory (immediate recall) in normal cognition ( 29274321) Multisite chronic pain ( 31194737) Weight ( 20966902)	Tonsillectomy ( 27182965 28928442)
Interacting Genes		7 interacting genes: ANAPC11 CDC20 CDC27 MAD2L1 MAD2L1BP UBE2I UBE2S	1 interacting genes: DTX2
Entrez ID		29945	51091
HPRD ID		09505	11561
Ensembl ID		ENSG00000053900	ENSG00000109618
Uniprot IDs		B3KN47 Q9UJX5	A1A4F3 Q9HD40
PDB IDs		4UI9 5A31 5BPW 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5	3HL2 4ZDL 4ZDO 4ZDP
Enriched GO Terms of Interacting Partners?
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