ANAPC4 and MAD2L1

Data Source:
BioGRID (pull down)

		ANAPC4	MAD2L1
Description		anaphase promoting complex subunit 4	mitotic arrest deficient 2 like 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Periphery	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Phosphatase Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Establishment Of Mitotic Spindle Orientation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Body size at age 10 ( 32376654) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Logical memory (immediate recall) in normal cognition ( 29274321) Multisite chronic pain ( 31194737) Weight ( 20966902)	Coronary artery disease ( 32469254 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: ANAPC11 CDC20 CDC27 MAD2L1 MAD2L1BP UBE2I UBE2S	26 interacting genes: ADAM17 ANAPC2 ANAPC4 APP CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD
Entrez ID		29945	4085
HPRD ID		09505	03274
Ensembl ID		ENSG00000053900	ENSG00000164109
Uniprot IDs		B3KN47 Q9UJX5	Q13257
PDB IDs		4UI9 5A31 5BPW 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5	1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ
Enriched GO Terms of Interacting Partners?
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