USP25 and ZNF426

Data Source:
BioGRID (two hybrid)

		USP25	ZNF426
Description		ubiquitin specific peptidase 25	zinc finger protein 426
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol	Nucleus
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Regulation Of Transcription By RNA Polymerase II
Pathways		Ub-specific processing proteases	Generic Transcription Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		21 interacting genes: ACTA1 FBXL17 FLNC GAPDH MAGEB4 MID2 MT2A PUS10 RAD23A RAD23B SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS UBC UBE2I ZNF426	45 interacting genes: ACTN3 ANKRD11 ARMC7 ATPAF2 BYSL CALCOCO2 CARD9 CCDC85B CCNC CDK18 CEP70 CIB3 CTNNA3 DUSP4 EFEMP2 ENKD1 FAM161A GLRX3 GSDMD HEXIM2 KCTD9 KRT3 KRTAP4-12 LNX1 LONRF1 LPXN LZTS2 MAGOHB MALSU1 MAP2K5 MDFI MPPE1 MTUS2 NATD1 NINL OPTN PARVG RFC5 RHOJ TEKT4 TSGA10 USP25 ZGPAT ZNF330 ZSCAN23
Entrez ID		29761	79088
HPRD ID		05296	15787
Ensembl ID		ENSG00000155313	ENSG00000130818
Uniprot IDs		Q9UHP3	A0A024R7D7 K7EME3 K7ER43 Q59EH4 Q9BUY5
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?
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