PDIA3 and SEC11A

Data Source:
BioGRID (affinity chromatography technology)

		PDIA3	SEC11A
Description		protein disulfide isomerase family A member 3	SEC11 homolog A, signal peptidase complex subunit
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Phosphopantetheinylation Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Peptide Processing
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379) Triglyceride levels ( 32203549)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes		21 interacting genes: APP BACE1 CALR CANX ERO1A ERP27 ESR1 GYPC HLA-A IFNG LGALS9 LINC01554 MDM2 MTNR1B PCAT1 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		2923	23478
HPRD ID		03625	07503
Ensembl ID		ENSG00000167004	ENSG00000140612
Uniprot IDs		P30101 V9HVY3	A0A024RC78 H0YKT4 P67812
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY
Enriched GO Terms of Interacting Partners?
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