GRM7 and TUBA1A

Data Source:
HPRD (in vivo, in vitro)

		GRM7	TUBA1A
Description		glutamate metabotropic receptor 7	tubulin alpha 1a
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone	Nucleus Cytoplasm Cytosol Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Neuromuscular Junction Cytoplasmic Ribonucleoprotein Granule Myelin Sheath Membrane Raft Recycling Endosome Extracellular Exosome
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Serine Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Negative Regulation Of Glutamate Secretion Regulation Of Cyclase Activity Regulation Of Synaptic Transmission, Glutamatergic	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Regulation Of Synapse Organization Cell Division Ciliary Basal Body-plasma Membrane Docking
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Glutamic acid	Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Airway imaging phenotypes ( 26030696) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Early response to risperidone in schizophrenia ( 26856250) Major depressive disorder (broad) ( 20038947) Night sleep phenotypes ( 27126917) Orofacial clefts ( 22419666) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Panic disorder ( 19165232) Personality traits in bipolar disorder ( 21368711) Plasma clusterin levels ( 26545630) Platelet reactivity in response to clopidogrel treatment ( 32472697) Recurrent major depressive disorder ( 29317602) Response to fenofibrate (total cholesterol levels) ( 27002377) Systemic sclerosis ( 30247649) Telomere length ( 30185882) Urate levels in lean individuals ( 25811787) Urinary albumin excretion ( 32277301) Uterine fibroid number (single vs multiple) ( 30196971) Visceral adipose tissue adjusted for BMI ( 22589738)	Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)
Interacting Genes		14 interacting genes: CALM1 CALM2 CALM3 FLNA GNAQ GRIP1 GRIPAP1 PICK1 SDCBP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8	63 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EML1 GEMIN7 GRM7 GSK3B GZMB HDAC6 HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 PAFAH1B1 PLA2G7 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK TAOK2 TBCB TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70
Entrez ID		2917	7846
HPRD ID		04979	03959
Ensembl ID		ENSG00000196277	ENSG00000167552
Uniprot IDs		B2R693 B9EGG9 Q14831 Q59G95	Q71U36
PDB IDs		3MQ4 5C5C	5JCO 6J8F 6WSL 7C1M
Enriched GO Terms of Interacting Partners?
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