UHRF1 and PCNA

Data Source:
BioGRID (enzymatic study)

		UHRF1	PCNA
Description		ubiquitin like with PHD and ring finger domains 1	proliferating cell nuclear antigen
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Nuclear Matrix	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Chromatin Nucleus Nuclear Lamina Nucleoplasm Replication Fork Centrosome Nuclear Body Replisome Nuclear Replication Fork PCNA Complex Extracellular Exosome PCNA-p21 Complex
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Chromatin Binding Damaged DNA Binding Protein Binding Protein C-terminus Binding Enzyme Binding Estrogen Receptor Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Histone Acetyltransferase Binding Identical Protein Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Maintenance Of DNA Methylation Histone Monoubiquitination Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Viral Process Protein Ubiquitination Translesion Synthesis Epithelial Cell Differentiation Replication Fork Processing Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Estradiol Nucleotide-excision Repair, DNA Incision Cellular Response To UV Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Estrous Cycle Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Error-free Translesion Synthesis Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Liver Regeneration Positive Regulation Of DNA-directed DNA Polymerase Activity Response To L-glutamate Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways		DNA methylation	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins
Drugs			Liothyronine Acetylsalicylic acid
Diseases
GWAS		Birth weight ( 31043758) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		26 interacting genes: DNMT1 DNMT3A ERCC1 ERG FANCD2 H2AC4 H2BC3 H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 LASP1 LIG1 MBD4 MUS81 PCLAF PCNA PRKACA TP53 UBE2D1 UBE2D3 UBE2N UHRF2	139 interacting genes: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CMTM5 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERCC6 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HUS1 HUWE1 IGF1R ING1 KCTD13 KMT5A LDHA LIG1 LMNA MCL1 MGMT MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A NMRAL1 NSD2 NTHL1 NUTF2 PARP1 PARP10 PARPBP PCLAF PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTEN PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RNF8 RPA1 SDE2 SEC23IP SIVA1 SLC30A8 SMARCAD1 SPG21 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 TRIM28 UBB UBE2A UBE2B UBE2D3 UHRF1 UNG USP1 USP2 USP4 WDR48 WRN WRNIP1 XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1
Entrez ID		29128	5111
HPRD ID		06992	01456
Ensembl ID		ENSG00000276043	ENSG00000132646
Uniprot IDs		A0A087WVR3 Q96T88	P12004
PDB IDs		2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED	1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG 6S1M 6S1N 6S1O 6TNY 6TNZ 6VVO
Enriched GO Terms of Interacting Partners?
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