MYLIP and HOOK2

Data Source:
BioGRID (two hybrid)

		MYLIP	HOOK2
Description		myosin regulatory light chain interacting protein	hook microtubule tethering protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex Intracellular Membrane-bounded Organelle FHF Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport
Pathways		VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		41 interacting genes: ADAMTSL4 AR ARID5A CNPY2 CRK DAPP1 DDIT4L EFHC2 EXOSC5 FAM217B GMCL1 HOOK2 INO80B KANK4 KDM1A LNX2 LRP8 MIPOL1 MTAP MYL12B NHLRC4 NOXA1 NR1D2 PAX9 RASSF5 SCNM1 SDCBP SRPK2 TCEANC TSC1 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR ZBTB16 ZBTB18 ZBTB42 ZNF417 ZNF438	121 interacting genes: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 ATG5 BYSL C1orf109 CABP2 CBX8 CCDC187 CCDC198 CCDC33 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13 EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEANC TCHP TPM3 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844
Entrez ID		29116	29911
HPRD ID		17621	09698
Ensembl ID		ENSG00000007944	ENSG00000095066
Uniprot IDs		Q5TIA5 Q8WY64	Q96ED9
PDB IDs		2YHN 2YHO 6QLY 6QLZ
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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