MRPS18B and EXOSC6

Data Source:
BioGRID (two hybrid)

		MRPS18B	EXOSC6
Description		mitochondrial ribosomal protein S18B	exosome component 6
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Cell Junction	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	Structural Constituent Of Ribosome Protein Binding	RNA Binding Exoribonuclease Activity
	Biological Process	Translation Mitochondrial Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Neuroblastoma (pediatric) ( 32599975) Waist circumference adjusted for body mass index ( 28552196)	Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		20 interacting genes: BMP10 CD81 CLEC1A ERCC6 EWSR1 EXOSC6 IGFBP5 LAT LRP10 MIP RB1 SEC22B SLC35A1 SYS1 TMED8 TMEM120B TMEM128 TNFRSF10C TRARG1 ZFPL1	37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		28973	118460
HPRD ID		14781	12107
Ensembl ID		ENSG00000204568	ENSG00000223496
Uniprot IDs		B0S7P4 Q9Y676	Q5RKV6
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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