SPCS1 and UBXN8

Data Source:
BioGRID (two hybrid)

		SPCS1	UBXN8
Description		signal peptidase complex subunit 1	UBX domain protein 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Ubiquitin Ligase Complex Nucleoplasm Nucleolus Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Molecular_function Protein Binding Peptidase Activity Ribosome Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER	Single Fertilization Ubiquitin-dependent ERAD Pathway
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AQP2 FIS1 FXYD6-FXYD2 NAALAD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2	7 interacting genes: AQP6 GJA8 HSD17B13 MEOX2 PGRMC2 SPCS1 TMEM14B
Entrez ID		28972	7993
HPRD ID		07155	03692
Ensembl ID		ENSG00000114902	ENSG00000104691
Uniprot IDs		Q9Y6A9	B4DKK1 O00124
PDB IDs
Enriched GO Terms of Interacting Partners?
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