GPT and CAPN1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GPT	CAPN1
Description		glutamic--pyruvic transaminase	calpain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	L-alanine:2-oxoglutarate Aminotransferase Activity Pyridoxal Phosphate Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity
	Biological Process	Cellular Amino Acid Biosynthetic Process Cellular Response To Insulin Stimulus Response To Starvation L-alanine Catabolic Process Positive Regulation Of Gluconeogenesis	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity
Pathways		Alanine metabolism	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Pyridoxal phosphate Glutamic acid Alanine Phenelzine	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Age at first birth ( 27798627) Alanine aminotransferase levels ( 30718733) Educational attainment ( 25201988) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273)	Urate levels ( 31578528)
Interacting Genes		2 interacting genes: CAPN1 CDC7	54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		2875	823
HPRD ID		00689	00253
Ensembl ID		ENSG00000167701	ENSG00000014216
Uniprot IDs		P24298	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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