RSPO1 and LGR4

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		RSPO1	LGR4
Description		R-spondin 1	leucine rich repeat containing G protein-coupled receptor 4
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GO Annotations	Cellular Component	Extracellular Region Nucleus	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Heparin Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Osteoblast Differentiation Negative Regulation Of Cytokine Production Hair Follicle Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Hormone-mediated Signaling Pathway Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Intestinal Stem Cell Homeostasis Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Digestive Tract Development Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Axial length ( 24144296) Epithelial ovarian cancer ( 25581431) Eyebrow thickness ( 26926045) Intraocular pressure ( 29785010 31959993 30054594)	Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23644456) Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Dental caries (decayed, missing and filled teeth) ( 31533690) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 25231870) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Survival in pancreatic cancer ( 28470677) Urate levels in obese individuals ( 25811787)
Interacting Genes		2 interacting genes: LGR4 ZNRF3	5 interacting genes: MARCHF2 RSPO1 RSPO2 RSPO3 RSPO4
Entrez ID		284654	55366
HPRD ID		08288	05978
Ensembl ID		ENSG00000169218	ENSG00000205213
Uniprot IDs		Q2MKA7	Q59ER8 Q9BXB1
PDB IDs		4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4CDK 4KNG 4KT1 4LI2 4QXF	4KT1 4QXE 4QXF
Enriched GO Terms of Interacting Partners?
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