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TMED8 and DERL1
Data Source:
BioGRID
(two hybrid)
TMED8
DERL1
Description
transmembrane p24 trafficking protein family member 8
derlin 1
Image
No pdb structure
GO Annotations
Cellular Component
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
Protein Binding
Protease Binding
Signal Recognition Particle Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
MHC Class I Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
ATPase Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Biological Process
Protein Folding
Response To Unfolded Protein
Viral Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Protein Binding
ERAD Pathway
Establishment Of Protein Localization
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Pathways
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Mean reticulocyte volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
32 interacting genes:
ADTRP
AMIGO2
APOL2
ARL6IP1
C10orf67
CIAO2A
CMTM5
CMTM6
CYB561D1
DEFB129
DERL1
DGAT2L6
EI24
H4C7
LAPTM4A
MDK
MMGT1
MRPL41
MRPS18B
MTIF3
NDUFA12
REEP6
SERP2
STX8
SUSD3
TMEM115
TMEM121
TMEM218
TMEM254
TRAM1L1
UNC50
ZDHHC16
33 interacting genes:
ABHD4
AMFR
APP
AQP6
CFTR
CIAO2A
FCRL4
FFAR2
GAD2
HLA-A
KASH5
LMNA
LNX1
MELTF
REEP4
RETREG3
RHO
SCN3B
SELENOS
SLC10A1
SLC10A6
SLC30A8
SLC7A14
SLC7A8
TCF25
TEX44
TMED8
TMEM31
TMX2
TRIM32
UBE2J1
UBXN6
VCP
Entrez ID
283578
79139
HPRD ID
18201
12302
Ensembl ID
ENSG00000100580
ENSG00000136986
Uniprot IDs
Q6PL24
A0A024R9G3
E5RGY0
Q9BUN8
PDB IDs
5GLF
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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