MORN3 and PRKAA2

Data Source:
BioGRID (two hybrid)

		MORN3	PRKAA2
Description		MORN repeat containing 3	protein kinase AMP-activated catalytic subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Neuronal Cell Body
	Molecular Function	Protein Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process		Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Lipid Biosynthetic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Macroautophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Drug Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Energy Homeostasis Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Peptidyl-lysine Acetylation
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS			Lymphocyte counts ( 22286170)
Interacting Genes		65 interacting genes: ABHD11 ADAMTSL4 ARID5A BEX2 C14orf119 CDCA7L CTDSP1 DYNLL1 DYNLL2 EIF3D ENKD1 FAM166B FAM90A1 FANCL FARS2 FTO GEM GLYCTK GOLGA2 GPANK1 GUCD1 HOOK2 HOXB2 IKZF3 INO80B KANK2 KLHL38 KRT15 LHX2 LZTS2 MAGEA6 MB21D2 MEOX2 MISP MKRN3 MLH1 MYOZ3 NDUFAB1 NFU1 NOXA1 NTAQ1 OIP5 PAX6 PHF1 PICK1 POLR1C PRKAA2 PRKAB2 PRR5L RBPMS RNF39 RSPH1 RUSC1 SCNM1 SH2D4A SOX5 SUOX TASOR2 TEKT4 TRAF1 TRAF2 TRIP13 YPEL3 ZNF438 ZNF76	122 interacting genes: ABI1 ABI2 ACACA ACACB AIMP2 AKAP8L AMOT AMOTL2 ANAPC11 APPBP2 ARRDC3 AVPI1 C19orf47 CALCOCO1 CALCOCO2 CCDC172 CCDC33 CCNB1IP1 CDC42EP1 CDR2 CDX4 CPSF7 CTAG2 CYSRT1 DNAAF6 DNM2 DNMT1 DVL3 EEF2K EMILIN1 EPM2A EPN2 FNDC3B FOS GIGYF1 GLI1 GOLGA2 GOLGA6A GRAP2 HAT1 HMBOX1 HNF4A HOMEZ IKZF1 IKZF3 KCTD1 KCTD9 KIAA1328 KIF16B KIF24 KIFC3 KRT16 KRT31 KRTAP1-3 KRTAP10-3 KRTAP10-9 L3MBTL3 LCN2 LEP LZTS2 MKRN3 MORN3 MRFAP1 MTUS2 MYCL MYOZ1 NAB2 NECAB2 NONO NOTCH2NLA NRAP NRBF2 NUTM1 PBXIP1 PFKFB2 PLEKHN1 PPP1R32 PRDM6 PRKAB1 PRKAG1 PRKAR1B PRKN PRPH RASAL3 RBBP7 RBPMS REL RFX6 RPTOR SERTAD3 SKIV2L SLA2 SNW1 SOHLH1 SPRY1 STAC2 STK11 TCF4 TFAP2A TIFA TLE5 TMOD1 TRIP13 TRIP6 TSC22D4 UBE2I USH1C USH1G USHBP1 USP10 VPS28 VPS37B VPS52 WASHC1 WWP1 WWP2 YPEL3 ZBTB8A ZMYND12 ZNF212 ZNF397 ZSCAN23
Entrez ID		283385	5563
HPRD ID		17330	02735
Ensembl ID		ENSG00000139714	ENSG00000162409
Uniprot IDs		Q6PF18	P54646
PDB IDs			2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6
Enriched GO Terms of Interacting Partners?
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