CRACR2B and IDH1

Data Source:
BioGRID (two hybrid)

		CRACR2B	IDH1
Description		calcium release activated channel regulator 2B	isocitrate dehydrogenase (NADP(+)) 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Calcium Ion Binding Protein Binding	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding NADP Binding NAD Binding
	Biological Process	Store-operated Calcium Entry Cellular Protein Localization Regulation Of Store-operated Calcium Entry	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome NADP Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Neutrophil Degranulation Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways			Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import
Drugs			Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib
Diseases
GWAS		Body mass index ( 29273807)	Adult diffuse glioma (IDH mutation) ( 32386320) Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		15 interacting genes: APP CA13 CCDC187 DNAAF4 IDH1 IL36RN LNX1 PSMB3 RIN1 TCEANC TSGA10IP TSHZ2 TXN2 USP2 ZBTB25	16 interacting genes: AGGF1 CALM1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 LAX1 LINC01554 NUP62 PEX5 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		283229	3417
HPRD ID		14645	00984
Ensembl ID		ENSG00000177685	ENSG00000138413
Uniprot IDs		Q8N4Y2	A0A024R3Y6 O75874
PDB IDs			1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F 6U4J 6VEI 6VG0
Enriched GO Terms of Interacting Partners?
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