GNG11 and REP15

Data Source:
BioGRID (two hybrid)

		GNG11	REP15
Description		G protein subunit gamma 11	RAB15 effector protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane G-protein Beta/gamma-subunit Complex	Endosome Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Receptor Recycling Transferrin Transport
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Heart rate ( 23583979) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Mosquito bite size ( 28199695) Resting heart rate ( 27798624)
Interacting Genes		9 interacting genes: AMOTL2 CEP44 FOS GNB1 GNB4 MEOX2 REP15 SMURF1 ZHX1	5 interacting genes: ARID3A EVI5 GNG11 ZRSR2 ZRSR2P1
Entrez ID		2791	387849
HPRD ID		11979	18804
Ensembl ID		ENSG00000127920	ENSG00000174236
Uniprot IDs		P61952 Q53Y01	Q6BDI9
PDB IDs
Enriched GO Terms of Interacting Partners?
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