GNB1 and GNG12

Data Source:
BioGRID (affinity chromatography technology, pull down)

		GNB1	GNG12
Description		G protein subunit beta 1	G protein subunit gamma 12
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Photoreceptor Outer Segment Membrane Cell Body Synapse Extracellular Exosome Photoreceptor Disc Membrane Extracellular Vesicle	Heterotrimeric G-protein Complex Actin Filament Plasma Membrane G-protein Beta/gamma-subunit Complex Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding Spectrin Binding G-protein Gamma-subunit Binding Protein-containing Complex Binding Alkylglycerophosphoethanolamine Phosphodiesterase Activity GTPase Binding	Protein Binding PDZ Domain Binding G-protein Beta-subunit Binding Phosphate Ion Binding
	Biological Process	Protein Folding Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Acetylcholine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Ras Protein Signal Transduction Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Platelet Activation Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Catecholamine Stimulus	Signal Transduction G Protein-coupled Receptor Signaling Pathway Cerebral Cortex Development Response To Lipopolysaccharide
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Body mass index ( 26426971 25673413) Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)	Feeling fed-up ( 29500382) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Thyroid stimulating hormone levels ( 32769997) Upper eyelid morphology ( 29921221)
Interacting Genes		43 interacting genes: ADRA2A ADRB2 AFP ARHGEF18 ARRB1 ATXN10 AVPR2 CACNA1A CACNA1B CACNA1C CDC42 CTNNA3 CYFIP1 DISC1 EPHA7 GNA12 GNAS GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 HDAC5 KCNJ3 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PTH1R RACK1 RASD1 RASD2 TBXA2R VAC14	7 interacting genes: CAPN1 FHL2 GNB1 GNB2 GNB3 GNB4 HDAC7
Entrez ID		2782	55970
HPRD ID		00766	13592
Ensembl ID		ENSG00000078369	ENSG00000172380
Uniprot IDs		A0A140VJJ8 B3KVK2 P62873	Q9UBI6
PDB IDs		4KFM 4PNK 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6KPF 6KPG 6LFM 6LFO 6LI3 6LMK 6LML 6M1H 6M1I 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OMM 6ORV 6OS9 6OSA 6OT0 6P9X 6P9Y 6PB0 6PB1 6PT0 6UUN 6UUS 6UVA 6VCB 6VMS 6VN7 6WHA 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XBJ 6XBK 6XBL 6XBM 7C2E 7CFM 7CFN 7K7L 7K7Z
Enriched GO Terms of Interacting Partners?
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