GNAT1 and F2R

Data Source:
HPRD (in vitro)

		GNAT1	F2R
Description		G protein subunit alpha transducin 1	coagulation factor II thrombin receptor
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Apical Plasma Membrane Photoreceptor Connecting Cilium Photoreceptor Outer Segment Membrane Neuronal Cell Body Photoreceptor Disc Membrane	Extracellular Region Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Acyl Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding GDP Binding Protein Kinase Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste G Protein-coupled Adenosine Receptor Signaling Pathway Protein Folding Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Cell Population Proliferation Response To Light Stimulus Response To Light Intensity Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Eye Photoreceptor Cell Development Detection Of Light Stimulus Involved In Visual Perception Sensory Perception Of Umami Taste Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus	Activation Of MAPKK Activity Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Platelet Dense Granule Organization Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Negative Regulation Of Renin Secretion Into Blood Stream
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Cacodylic acid Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion	Streptokinase SR-123781A Vorapaxar Thrombin
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Mean platelet volume ( 22139419) Platelet count ( 22139419) Platelet distribution width ( 27863252)
Interacting Genes		3 interacting genes: F2R RGS16 RGS9	19 interacting genes: ARRDC3 ATP13A2 CAPN1 CHRD CTSG CXCL14 ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNX1
Entrez ID		2779	2149
HPRD ID		08850	01763
Ensembl ID		ENSG00000114349	ENSG00000181104
Uniprot IDs		A1LQ23 P11488	A0A024RAP7 P25116
PDB IDs		3RBQ	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7
Enriched GO Terms of Interacting Partners?
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