PRPF19 and DNTT

Data Source:
HPRD (in vivo, in vitro)

		PRPF19	DNTT
Description		pre-mRNA processing factor 19	DNA nucleotidylexotransferase
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Droplet Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	DNA Binding DNA-directed DNA Polymerase Activity DNA Nucleotidylexotransferase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Cellular Protein Localization Positive Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint	DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Response To ATP DNA Biosynthetic Process
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs			2',3'-Dideoxyadenosine triphosphate
Diseases
GWAS
Interacting Genes		14 interacting genes: DDX42 DNTT EGLN3 ESR1 EXOC7 GSTK1 HSPB1 POLR2A PRPF8 PSMB4 PTEN RPA3 U2AF1 UBE2D3	9 interacting genes: ABTB2 DNTTIP1 DNTTIP2 MEI4 PCNA PRPF19 REL TCF4 XRCC6
Entrez ID		27339	1791
HPRD ID		12214	08925
Ensembl ID		ENSG00000110107	ENSG00000107447
Uniprot IDs		Q9UMS4	P04053
PDB IDs		4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P	2COE 5W4E
Enriched GO Terms of Interacting Partners?
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