APEX2 and NINL

Data Source:
HPRD (two hybrid)

		APEX2	NINL
Description		apurinic/apyrimidinic endodeoxyribonuclease 2	ninein like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle	Centrosome Cytosol Microtubule Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Phosphodiesterase I Activity Protein Binding Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity	Calcium Ion Binding Protein Binding
	Biological Process	Base-excision Repair DNA Recombination Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Anchoring At Centrosome Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)
Interacting Genes		17 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 MKRN3 NEDD4L NINL PCNA PGR TRAF2 TRIM37 TSHZ3	51 interacting genes: AKAP17A APEX2 AURKB CBY2 CCDC130 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSPYL4 UTP14A ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		27301	22981
HPRD ID		06442	11120
Ensembl ID		ENSG00000169188	ENSG00000101004
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q9Y2I6
PDB IDs
Enriched GO Terms of Interacting Partners?
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