GCLC and CCL22

Data Source:
BioGRID (two hybrid)

		GCLC	CCL22
Description		glutamate-cysteine ligase catalytic subunit	C-C motif chemokine ligand 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex	Extracellular Region Extracellular Space
	Molecular Function	Magnesium Ion Binding Glutamate-cysteine Ligase Activity Protein Binding ATP Binding Glutamate Binding ADP Binding	Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Heat Response To Hormone Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Blood Vessel Diameter Maintenance	Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)	Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		Glutamic acid Cysteine
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Benign prostatic hyperplasia ( 30988330) Birth weight ( 31043758) Daytime sleep phenotypes ( 27126917) Monocyte percentage of white cells ( 32888494) Waist circumference ( 28552196)	Asthma ( 32296059) Blood protein levels ( 30072576 29875488) Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 28714469)
Interacting Genes		1 interacting genes: CCL22	10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1
Entrez ID		2729	6367
HPRD ID		06032	04263
Ensembl ID		ENSG00000001084	ENSG00000102962
Uniprot IDs		E1CEI4 P48506 Q14TF0	O00626
PDB IDs
Enriched GO Terms of Interacting Partners?
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