VENTX and TBX22

Data Source:
BioGRID (two hybrid)

		VENTX	TBX22
Description		VENT homeobox	T-box transcription factor 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Heart Looping Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Transcription, DNA-templated
Pathways		Senescence-Associated Secretory Phenotype (SASP) Transcriptional Regulation by VENTX
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Cleft palate with ankyloglossia
GWAS			Nose size ( 27182965)
Interacting Genes		93 interacting genes: ABHD11 ADAMTSL4 ARID5A ARSA ATXN7L1 BATF2 BHLHE40 C10orf55 C19orf54 C1orf94 C6orf15 CEACAM6 CERCAM CES1 CFP CREM CSN3 CTAG1A CTAG1B CYSRT1 DAB1 DAZAP2 FAM168B FAM86C1P GLIS2 HOXC8 HYPK INTS11 IRF9 ITIH6 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-4 KRTAP13-1 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LITAF LYG1 MAGED1 MIEN1 ODAM PLA2G2F PLEKHB1 POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX1 RBPMS RHOXF2 RNF144B RNF4 ROR2 RSKR SLC15A2 SMUG1 SOX14 SPRY4 SYNGAP1 TBX15 TBX19 TBX22 TEKT5 TLE2 TMBIM4 TMEM42 TRIP13 TSC1 UBAP2 UBE2I UBQLN2 USP54 VAC14 VHLL WWOX YPEL3 ZBTB32 ZNF34	6 interacting genes: APP HOXC8 PITX1 PROP1 TLX3 VENTX
Entrez ID		27287	50945
HPRD ID		06197	02253
Ensembl ID		ENSG00000151650	ENSG00000122145
Uniprot IDs		O95231	B3KUL8 Q9Y458
PDB IDs
Enriched GO Terms of Interacting Partners?
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