GNMT and CTNS

Data Source:
BioGRID (two hybrid)

		GNMT	CTNS
Description		glycine N-methyltransferase	cystinosin, lysosomal cystine transporter
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Lysosome Lysosomal Membrane Early Endosome Late Endosome Vacuolar Membrane Plasma Membrane Integral Component Of Membrane Melanosome Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	L-cystine Transmembrane Transporter Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Lens Development In Camera-type Eye Cellular Amino Acid Metabolic Process Glutathione Metabolic Process Ion Transport Brain Development Long-term Memory Grooming Behavior Adult Walking Behavior Visual Learning Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Mitochondrial Membrane Potential L-cystine Transport Melanin Biosynthetic Process ATP Metabolic Process Cognition Transmembrane Transport
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation	Transport of inorganic cations/anions and amino acids/oligopeptides Miscellaneous transport and binding events
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine	Cystine
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency	Cystinosis
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		30 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	1 interacting genes: GNMT
Entrez ID		27232	1497
HPRD ID		05970	05885
Ensembl ID		ENSG00000124713	ENSG00000040531
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	A0A0S2Z3I9 A0A0S2Z3K3 I3L4A9 O60931
PDB IDs		1R74 2AZT
Enriched GO Terms of Interacting Partners?
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