C5AR2 and SCRIB

Data Source:
BioGRID (two hybrid)

		C5AR2	SCRIB
Description		complement component 5a receptor 2	scribble planar cell polarity protein
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Immunological Synapse Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Lamellipodium Cell Junction Cell Leading Edge Scrib-APC-beta-catenin Complex Presynaptic Membrane Postsynaptic Membrane Extracellular Exosome
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding	Protein Binding Cadherin Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis	Establishment Of T Cell Polarity Neural Tube Closure Positive Regulation Of Receptor Recycling Cell Population Proliferation Embryo Development Cell Migration Mitigation Of Host Immune Response By Virus Polarized Epithelial Cell Differentiation Positive Regulation Of Interferon-gamma Production Establishment Of Apical/basal Cell Polarity Suppression By Virus Of Host STAT1 Activity Suppression By Virus Of Host STAT2 Activity Positive Regulation Of Apoptotic Process Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Activated T Cell Proliferation Positive Chemotaxis Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction Activation Of GTPase Activity Receptor Localization To Synapse Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome
Pathways		Peptide ligand-binding receptors Regulation of Complement cascade	Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS			Menarche (age at onset) ( 25231870)
Interacting Genes		17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234	12 interacting genes: APC ARHGEF7 C5AR2 EXOSC10 LPP MAPK3 PRKCA STX4 TJP2 TRIP6 TSHR UBE3A
Entrez ID		27202	23513
HPRD ID		17072	06984
Ensembl ID		ENSG00000134830	ENSG00000180900
Uniprot IDs		Q9P296	A0A0G2JNZ2 A0A0G2JPP5 A0PJK8 Q14160
PDB IDs			1UJU 1WHA 1X5Q 2W4F 4WYT 4WYU 5VWC 5VWI 5VWK 6EEY 6ESP 6MS1 6MTU 6MTV 6MYE 6MYF
Enriched GO Terms of Interacting Partners?
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