GPC3 and WNT7B

Data Source:
HPRD (in vivo)

		GPC3	WNT7B
Description		glypican 3	Wnt family member 7B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Intrinsic Component Of Plasma Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Exosome
	Molecular Function	Protein Binding Peptidyl-dipeptidase Inhibitor Activity	Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Retinoid Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Response To Bacterium Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Body Morphogenesis Negative Regulation Of Peptidase Activity Cell Migration Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Cell Migration Involved In Gastrulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	In Utero Embryonic Development Metanephros Morphogenesis Wnt Signaling Pathway Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Forebrain Regionalization Central Nervous System Vasculogenesis Neuron Differentiation Lung Development Oxygen Homeostasis Homeostatic Process Cellular Metabolic Process Cell Fate Commitment Positive Regulation Of Osteoblast Differentiation Positive Regulation Of JNK Cascade Fibroblast Proliferation Embryonic Organ Development Synapse Organization Canonical Wnt Signaling Pathway Lung Morphogenesis Lung Epithelium Development Lobar Bronchus Development Trachea Cartilage Morphogenesis Developmental Growth Involved In Morphogenesis Embryonic Placenta Morphogenesis Chorio-allantoic Fusion Mammary Gland Epithelium Development Lens Fiber Cell Development Cellular Response To Retinoic Acid Renal Inner Medulla Development Renal Outer Medulla Development Outer Medullary Collecting Duct Development Inner Medullary Collecting Duct Development Stem Cell Proliferation Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Loop Of Henle Development
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Educational attainment (years of education) ( 30038396) Relative hand skill ( 24068947)	Body mass index ( 25760438) Central corneal thickness ( 28171582 29847655) Corneal curvature ( 25823570) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Macular thickness ( 30535121) Optic disc size ( 31809533) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Type 2 diabetes ( 32499647)
Interacting Genes		6 interacting genes: APPL1 FGF2 IGF2 PTPRS WNT3A WNT7B	5 interacting genes: CASK CUL3 ELOC GPC3 PORCN
Entrez ID		2719	7477
HPRD ID		02074	03573
Ensembl ID		ENSG00000147257	ENSG00000188064
Uniprot IDs		B4DTD8 I6QTG3 P51654 Q53H15	A8K0G1 P56706
PDB IDs
Enriched GO Terms of Interacting Partners?
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