DISC1 and CTNNA3

Data Source:
BioGRID (two hybrid)

		DISC1	CTNNA3
Description		DISC1 scaffold protein	catenin alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Centrosome Cytosol Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base	Cytosol Cytoskeleton Adherens Junction Fascia Adherens Lamellipodium
	Molecular Function	Protein Binding Kinesin Binding Protein-containing Complex Binding Molecular Adaptor Activity	Protein Binding Beta-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Proliferation In Forebrain Pyramidal Neuron Migration Positive Regulation Of Wnt Signaling Pathway TOR Signaling Negative Regulation Of Protein Binding Positive Regulation Of Axon Extension Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Protein Localization To Centrosome Regulation Of Synapse Maturation Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Actin Filament Organization Cell Migration Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)	Adventurousness ( 30643258) Adverse response to drug ( 30420678) Asthma (toluene diisocyanate-induced) ( 19187332) Bronchopulmonary dysplasia ( 23897914) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries ( 23064961) Diffusing capacity of carbon monoxide ( 30694715) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Essential tremor ( 27797806) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Metabolite levels (Pyroglutamine) ( 23934736) Mitochondrial DNA copy number ( 30704525) Nickel levels ( 26025379) Nicotine dependence ( 17158188) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Optic disc area ( 28073927) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878) Schizophrenia (cytomegalovirus infection interaction) ( 23358160) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878)
Interacting Genes		188 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AKAP6 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BORCS6 BRD1 C1orf109 C2CD6 C8orf33 CARD9 CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57 CEP57L1 CEP63 CFAP206 CIT CLU COL4A1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GAS8 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT20 IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK RNF40 ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TNKS TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76	68 interacting genes: AKAP9 ATP23 BLOC1S2 BLZF1 C17orf50 CCDC183 CCDC33 CDSN CENPS-CORT CKMT1A CKMT1B CMC2 COG4 CRX CTNNB1 DISC1 ECSIT EID2B EPS8 FAM110A FAM161A FAM161B FAM9A FBXO28 FERD3L GINS3 GNB1 HDX HOMEZ JUP KATNAL1 LASP1 MARCHF7 MBD3L1 MSRA MYOG NAB2 NDUFB7 OIP5 ORC2 PAX6 PLAGL2 PNMA1 PNMA5 POU6F2 PPARA PRR5 REL RIPPLY1 RPS6KA5 SERTAD2 SPATS1 STMN2 TASOR2 TLX3 TNNI1 TNNI2 TRIM54 TXNRD3 USHBP1 VIP ZG16 ZNF19 ZNF426 ZNF474 ZNF552 ZNF620 ZNF662
Entrez ID		27185	29119
HPRD ID		05553	09639
Ensembl ID		ENSG00000162946	ENSG00000183230
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	A8K141 Q8WW10 Q9UI47
PDB IDs		5V4B
Enriched GO Terms of Interacting Partners?
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