AFF4 and CCNT1

Data Source:
HPRD (in vivo)

		AFF4	CCNT1
Description		AF4/FMR2 family member 4	cyclin T1
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Transcription Elongation Factor Complex Super Elongation Complex Transcriptionally Active Chromatin	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Spermatid Development Regulation Of Gene Expression	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle Viral Process Positive Regulation Of DNA-templated Transcription, Elongation SnRNA Transcription By RNA Polymerase II Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Cell Division Negative Regulation Of MRNA Polyadenylation
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Asthma ( 31619474) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		11 interacting genes: AP2B1 CCNT1 CDK9 ELL2 GOLGA2 LRRK2 MLLT1 MTUS2 SIAH1 SPP1 TRAF2	26 interacting genes: AFF4 AHR BRD4 CDK9 CEBPB ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2 SUPT5H
Entrez ID		27125	904
HPRD ID		09187	03938
Ensembl ID		ENSG00000072364	ENSG00000129315
Uniprot IDs		Q9UHB7	A8K4M5 O60563
PDB IDs		4IMY 4OGR 4OR5 5JW9 5L1Z 6CYT 6K7P 6KN5 6R80	2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH
Enriched GO Terms of Interacting Partners?
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