FOXP1 and FOXP4

Data Source:
HPRD (two hybrid, in vitro)

		FOXP1	FOXP4
Description		forkhead box P1	forkhead box P4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Protein Self-association Metal Ion Binding Androgen Receptor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Osteoclast Differentiation Response To Lipopolysaccharide Interleukin-21 Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-12 Production Regulation Of Tumor Necrosis Factor Production Somatic Stem Cell Population Maintenance Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway T Follicular Helper Cell Differentiation Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Anorexia nervosa ( 31308545) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 31527586) Basal cell carcinoma ( 31174203 27539887) Beef consumption ( 32066663) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 32041948) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Esophageal adenocarcinoma ( 24121790) Familial lung adenocarcinoma ( 29924316) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hand grip strength ( 29691431) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998 24002674 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-melanoma skin cancer ( 29739929) Nose size ( 27182965) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Optic disc size ( 31809533) Pork consumption ( 32066663) PR interval ( 32439900) Primary sclerosing cholangitis ( 27992413) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Selective IgA deficiency ( 27723758) Squamous cell carcinoma ( 26829030) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 27841878) Tooth agenesis (maxillary lateral incisors) ( 29364747) Vitiligo ( 27723757) White blood cell count ( 32888494)	Chronotype ( 30696823) EGFR mutation-positive lung adenocarcinoma ( 27501781) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Non-small cell lung cancer ( 31326317) Prostate cancer ( 20676098 31562322)
Interacting Genes		9 interacting genes: AURKA CTBP1 FOXP2 FOXP4 IKZF1 IL3RA LRRK1 MNAT1 NCOR2	3 interacting genes: FOXP1 FOXP2 XAGE2
Entrez ID		27086	116113
HPRD ID		18518	10600
Ensembl ID		ENSG00000114861	ENSG00000137166
Uniprot IDs		A0A3B3IT66 Q548T7 Q8N2P0 Q8TEA2 Q9H334	Q8IVH2
PDB IDs		2KIU
Enriched GO Terms of Interacting Partners?
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