GGCX and PROC

Data Source:
HPRD (in vitro)

		GGCX	PROC
Description		gamma-glutamyl carboxylase	protein C, inactivator of coagulation factors Va and VIIIa
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Gamma-glutamyl Carboxylase Activity Vitamin Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Inherited thrombophilia
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		2677	5624
HPRD ID		00665	01466
Ensembl ID		ENSG00000115486	ENSG00000115718
Uniprot IDs		P38435	P04070
PDB IDs			1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C
Enriched GO Terms of Interacting Partners?
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