GGCX and PPM1G

Data Source:
BioGRID (affinity chromatography technology)

		GGCX	PPM1G
Description		gamma-glutamyl carboxylase	protein phosphatase, Mg2+/Mn2+ dependent 1G
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Gamma-glutamyl Carboxylase Activity Vitamin Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation	Protein Dephosphorylation Cell Cycle Arrest Peptidyl-threonine Dephosphorylation
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs		Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Bone mineral density (total hip) ( 29883787) Creatinine levels ( 31015462) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Non-oily fish consumption ( 32066663) Takayasu arteritis ( 25604533) Triglyceride levels ( 31928498)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	10 interacting genes: FBXO38 GRIA3 H3-4 LRPAP1 MSL1 MTNR1B RPS6KA1 TERF1 TERF2 TERF2IP
Entrez ID		2677	5496
HPRD ID		00665	09237
Ensembl ID		ENSG00000115486	ENSG00000115241
Uniprot IDs		P38435	O15355 Q6IAU5
PDB IDs
Enriched GO Terms of Interacting Partners?
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