GFER and COPS2

Data Source:
HPRD (in vivo)

		GFER	COPS2
Description		growth factor, augmenter of liver regeneration	COP9 signalosome subunit 2
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GO Annotations	Cellular Component	Extracellular Region Mitochondrion Mitochondrial Intermembrane Space Cytosol	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	Protein Binding Growth Factor Activity Protein Disulfide Oxidoreductase Activity Flavin-linked Sulfhydryl Oxidase Activity Flavin Adenine Dinucleotide Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Liver Development Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Mitochondrial protein import	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs		Flavin adenine dinucleotide
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		7 interacting genes: ASCC2 BNIPL COPS2 COPS5 PLEKHF2 SMAD2 TXN	38 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446
Entrez ID		2671	9318
HPRD ID		02954	05146
Ensembl ID		ENSG00000127554	ENSG00000166200
Uniprot IDs		P55789	P61201 Q59EL2
PDB IDs		3MBG 3O55 3TK0 3U2L 3U2M 3U5S 4LDK	4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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