GFER and MTRR

Data Source:
HPRD (in vitro)

		GFER	MTRR
Description		growth factor, augmenter of liver regeneration	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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GO Annotations	Cellular Component	Extracellular Region Mitochondrion Mitochondrial Intermembrane Space Cytosol	Nucleoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Growth Factor Activity Protein Disulfide Oxidoreductase Activity Flavin-linked Sulfhydryl Oxidase Activity Flavin Adenine Dinucleotide Binding	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding NADPH Binding FAD Binding
	Biological Process	Liver Development Signal Transduction	Sulfur Amino Acid Metabolic Process DNA Methylation Methionine Metabolic Process Methionine Biosynthetic Process Cobalamin Metabolic Process Methylation S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Negative Regulation Of Cystathionine Beta-synthase Activity
Pathways		Mitochondrial protein import	Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Drugs		Flavin adenine dinucleotide	Cyanocobalamin Methionine
Diseases			Spina bifida Homocystinuria
GWAS			Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		7 interacting genes: ASCC2 BNIPL COPS2 COPS5 PLEKHF2 SMAD2 TXN	2 interacting genes: GMCL1 MMAB
Entrez ID		2671	4552
HPRD ID		02954	03979
Ensembl ID		ENSG00000127554	ENSG00000124275
Uniprot IDs		P55789	Q9UBK8
PDB IDs		3MBG 3O55 3TK0 3U2L 3U2M 3U5S 4LDK	2QTL 2QTZ
Enriched GO Terms of Interacting Partners?
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