AMFR and UBL4A

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology)

		AMFR	UBL4A
Description		autocrine motility factor receptor	ubiquitin like 4A
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane BAT3 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Chaperone Binding
	Biological Process	Protein Polyubiquitination Protein Folding Ubiquitin-dependent Protein Catabolic Process Signal Transduction Aging Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	Cellular Protein Modification Process Protein Phosphopantetheinylation Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)	Neutrophil count ( 32888494)
Interacting Genes		28 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 SOD1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	14 interacting genes: AMFR APP CDCA7L ERP27 MEOX2 PER2 RNF126 S100P SEC61B SGTA SGTB TRAF4 TRIM54 USP13
Entrez ID		267	8266
HPRD ID		09130	02417
Ensembl ID		ENSG00000159461	ENSG00000102178
Uniprot IDs		A0A024R6R5 Q9UKV5	P11441
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD	2DZI 4WWR 4X86
Enriched GO Terms of Interacting Partners?
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