GDF9 and BMP15

Data Source:
HPRD (in vitro)

		GDF9	BMP15
Description		growth differentiation factor 9	bone morphogenetic protein 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding
	Biological Process	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway SMAD Protein Signal Transduction Regulation Of Progesterone Secretion	Ovarian Follicle Development Female Gamete Generation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Granulosa Cell Development SMAD Protein Signal Transduction
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Asthma ( 31619474)
Interacting Genes		45 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3 WASHC3	2 interacting genes: BMPR1B GDF9
Entrez ID		2661	9210
HPRD ID		03560	02216
Ensembl ID		ENSG00000164404	ENSG00000130385
Uniprot IDs		B4DXG3 O60383	O95972
PDB IDs
Enriched GO Terms of Interacting Partners?
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