FBXL5 and IREB2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FBXL5	IREB2
Description		F-box and leucine rich repeat protein 5	iron responsive element binding protein 2
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protein Polyubiquitination Cellular Iron Ion Homeostasis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Post-embryonic Development Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis Intestinal Absorption Iron Ion Homeostasis
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation	Iron uptake and transport
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 25241909 22080838 20173748) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 25056061 29483656)
Interacting Genes		11 interacting genes: CITED2 CSNK2B DCTN1 EP300 IREB2 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA	6 interacting genes: APP FBXL5 RBCK1 TERT USP53 YBX1
Entrez ID		26234	3658
HPRD ID		05739	08858
Ensembl ID		ENSG00000118564	ENSG00000136381
Uniprot IDs		Q9UKA1	D3DW85 P48200
PDB IDs		3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD	6VCD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?