PTPN22 and CD247

Data Source:
HPRD (in vivo)

		PTPN22	CD247
Description		protein tyrosine phosphatase non-receptor type 22	CD247 molecule
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Protein Dephosphorylation Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Phosphoanandamide Dephosphorylation Negative Regulation Of JUN Kinase Activity Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of Granzyme B Production Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of P38MAPK Cascade Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Surface
Pathways		Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
Drugs			Muromonab
Diseases		Type I diabetes mellitus
GWAS		Alopecia areata ( 25608926) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 21102463 23128233) Giant cell arteritis ( 25817017) Granulocyte count ( 27863252) Graves' disease ( 22922229) Gut microbiota (bacterial taxa) ( 27694959) Hashimoto thyroiditis ( 22922229) Hodgkin's lymphoma ( 30194254) Hypothyroidism ( 27182965 22493691) Idiopathic inflammatory myopathy ( 26362759) IgM levels ( 28628107) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Lymphocyte counts ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Myasthenia gravis ( 23055271) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Rheumatoid arthritis ( 24449572 17804836 30891314 30423114 18794853 17554300 21156761 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid peroxidase antibody levels ( 24586183) Type 1 diabetes ( 21829393 17632545 25751624 19430480 17554260 17554300 30572963 18978792) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)
Interacting Genes		12 interacting genes: CBL CD247 CD3E CLK1 CSK EGFR GRB2 LCK PRKCD SRPK2 VAV1 ZAP70	38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		26191	919
HPRD ID		06100	01729
Ensembl ID		ENSG00000134242	ENSG00000198821
Uniprot IDs		B4DZW8 G3K0T4 Q9Y2R2	P20963
PDB IDs		2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR
Enriched GO Terms of Interacting Partners?
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