GARS1 and GSDME

Data Source:
BioGRID (proximity labelling technology)

		GARS1	GSDME
Description		glycyl-tRNA synthetase 1	gasdermin E
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Extracellular Exosome	Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Protein Dimerization Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		Glycine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)	Deafness, autosomal dominant
GWAS
Interacting Genes		11 interacting genes: CD44 CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8	3 interacting genes: ITGB1BP1 PTN TIFA
Entrez ID		2617	1687
HPRD ID		02617	02996
Ensembl ID		ENSG00000106105	ENSG00000105928
Uniprot IDs		A0A090N8G0 A0A6Q8PGW4 P41250	A0A024RA58 A4FVA8 O60443
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M
Enriched GO Terms of Interacting Partners?
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