TES and ARAP1

Data Source:
BioGRID (two hybrid)

		TES	ARAP1
Description		testin LIM domain protein	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Focal Adhesion Cell Junction Protein-containing Complex	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Cadherin Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways			Rho GTPase cycle PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Drugs
Diseases
GWAS		Chronotype ( 30696823) Glaucoma ( 31959993 30054594) Intraocular pressure ( 31959993 30054594 29235454) Metabolite levels ( 23823483)	Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body mass index ( 28892062 25673413) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		13 interacting genes: ACTL7A ACTN1 ALKBH4 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX	14 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6
Entrez ID		26136	116985
HPRD ID		05833	09440
Ensembl ID		ENSG00000135269	ENSG00000186635
Uniprot IDs		A4D0U5 Q9UGI8	Q96P48
PDB IDs		2IYB 2XQN	4X1V
Enriched GO Terms of Interacting Partners?
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