AOC1 and FGD1

Data Source:
HPRD (in vitro, in vivo)

		AOC1	FGD1
Description		amine oxidase copper containing 1	FYVE, RhoGEF and PH domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Peroxisome Plasma Membrane Bicellular Tight Junction Specific Granule Lumen Extracellular Exosome	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Amine Oxidase Activity Heparin Binding Zinc Ion Binding Protein Homodimerization Activity Protein-containing Complex Binding Quinone Binding Diamine Oxidase Activity Histamine Oxidase Activity Methylputrescine Oxidase Activity Propane-1,3-diamine Oxidase Activity	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Xenobiotic Metabolic Process Amine Metabolic Process Putrescine Metabolic Process Cellular Response To Copper Ion Starvation Neutrophil Degranulation Response To Antibiotic Cellular Response To Copper Ion Cellular Response To Histamine Cellular Response To Heparin Cellular Response To Azide	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Phase I - Functionalization of compounds Neutrophil degranulation	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs		Amiloride Calcium Diminazene
Diseases			Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS		Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Carpal tunnel syndrome ( 30833571) Eyebrow thickness ( 26926045) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Urinary metabolite levels in chronic kidney disease ( 31959995)	Prostate cancer ( 31562322)
Interacting Genes		13 interacting genes: CYB561A3 DAO DAZAP2 DNM2 FGD1 FOXH1 KRTAP8-1 NTAQ1 POGZ RBPMS2 TIAL1 TLX3 ZC3H10	5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1
Entrez ID		26	2245
HPRD ID		00088	02373
Ensembl ID		ENSG00000002726	ENSG00000102302
Uniprot IDs		P19801	A0A024R9Y5 P98174
PDB IDs		3HI7 3HIG 3HII 3K5T 3MPH
Enriched GO Terms of Interacting Partners?
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