KANK2 and RAB11FIP2

Data Source:
BioGRID (two hybrid)

		KANK2	RAB11FIP2
Description		KN motif and ankyrin repeat domains 2	RAB11 family interacting protein 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Phagocytic Cup Nucleoplasm Endosome Cytoplasmic Vesicle Membrane Cell Projection Intracellular Membrane-bounded Organelle Recycling Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Glomerular Visceral Epithelial Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Renal Water Homeostasis Phagocytosis Establishment Of Cell Polarity TRAM-dependent Toll-like Receptor 4 Signaling Pathway Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of GTPase Activity Regulated Exocytosis Positive Regulation Of Protein Localization To Plasma Membrane
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 29212778) HDL cholesterol ( 23505323) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 31959993) Low density lipoprotein cholesterol levels ( 32154731) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels ( 32203549)	Age spots ( 29895819) Asthma (sex interaction) ( 24824216) Celiac disease ( 23936387) Freckles ( 29895819) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 30993211 29403010)
Interacting Genes		185 interacting genes: ABI3 AEN ANKRD11 AP2B1 ARL14EP ASB15 BEND7 BIRC7 BLZF1 BORCS6 C11orf1 C2orf68 CADPS CAMK2G CAPN3 CARD10 CARD9 CBX8 CCDC33 CCDC57 CCDC88B CDC20B CDC5L CDKL3 CEACAM6 CEP55 CEP63 CEP70 CHCHD3 CHIC2 CINP COG6 CRX CSNK2A1 CUTC CWF19L2 CYTH4 DDIT4L DLGAP3 DPEP2NB DTX2 DYNLL1 DYNLL2 EFHC2 EIF4E ELOA EXOSC8 FAM161A FAM90A1 FHL2 FHL3 FKBP6 GADD45GIP1 GATA1 GEMIN4 GKAP1 GMCL1 GMNN GOLGA2 GOLGA6A GOLGA6L9 GPANK1 GPKOW GPSM1 GRB10 HAND2 HOMER3 HSF2BP HSPB2 HSPB2-C11orf52 IHO1 IKZF3 IL16 KIF9 KIFAP3 KIFC3 KRT27 KRT34 KRT40 KRT75 KRT86 KRTAP6-3 L3MBTL3 LBX1 LENG1 LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LZTS1 MAGEB4 MCCD1 MCRS1 MED19 MEOX1 MEOX2 MID2 MITD1 MKRN3 MOB1A MOB3C MORN3 MSS51 MTUS2 MYOZ3 NCOA1 NCOA5 NECAB2 NOS3 NUTM1 OIP5 PAX6 PCBD1 PDE9A PDLIM7 PFDN6 PIBF1 PLAGL2 PLEKHA2 PNKP PPP1CB PRDM14 PRDM6 PRKAR1B PRMT5 PRPF18 PRPF31 PRR5L PSEN1 PSMB4 PSTPIP1 RAB11FIP2 RALBP1 RBCK1 RHOH SCARA5 SCNM1 SERTAD3 SNAPIN SNW1 SORBS3 SRPK2 STAC SYT6 TAX1BP1 TEX11 TFIP11 TGM5 THAP1 THAP6 TIFA TLE5 TOP3B TRAF1 TRAF2 TRAF4 TRIB3 TRIM35 TRIM54 TSGA10 TSGA10IP TSPYL6 TXLNA UBAP2 USHBP1 UTP14C VMAC VPS52 VWC2 WASF3 WASHC1 ZBTB42 ZFP57 ZMAT2 ZMYND12 ZNF212 ZNF414 ZNF512 ZNF648 ZNF774 ZNF784 ZNHIT1 ZRANB1	20 interacting genes: AP2A1 CXCR2 EHD1 FAM90A1 FBXO17 FKBP6 HSF2BP ITSN1 KANK2 LRRK2 MARK2 MYO5B PIBF1 RAB11A RAB11B RAB11FIP4 RAB25 REPS1 YWHAE YWHAG
Entrez ID		25959	22841
HPRD ID		12463	10548
Ensembl ID		ENSG00000197256	ENSG00000107560
Uniprot IDs		Q63ZY3	Q7L804
PDB IDs		4HBD 5YBV	2GZD 2GZH 2K6S 3TSO 4C4P 6S8X
Enriched GO Terms of Interacting Partners?
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