WWTR1 and TEAD3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		WWTR1	TEAD3
Description		WW domain containing transcription regulator 1	TEA domain transcription factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Nuclear Body	Chromatin Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Female Pregnancy Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Asymmetric Neuroblast Division
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS		Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011)	Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Offspring birth weight ( 31043758)
Interacting Genes		22 interacting genes: C1orf74 DAPK1 IL16 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PPP1CA RTN4IP1 RUNX1 SLC9A3R2 SUMO3 TCP11L1 TEAD1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ	15 interacting genes: AP4S1 CTBP2 E2F1 E2F3 KIFC2 MYH7 PHB2 PIDD1 SUMO2 VGLL1 VGLL2 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		25937	7005
HPRD ID		09580	04411
Ensembl ID		ENSG00000018408	ENSG00000007866
Uniprot IDs		Q9GZV5	Q99594
PDB IDs		5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX	5EMW
Enriched GO Terms of Interacting Partners?
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