POT1 and BAG3

Data Source:
BioGRID (two hybrid)

		POT1	BAG3
Description		protection of telomeres 1	BAG cochaperone 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Shelterin Complex	Stress Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Z Disc Neuron Projection Chaperone Complex
	Molecular Function	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Heat Shock Protein Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Chaperone Binding
	Biological Process	Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Regulation Of DNA Helicase Activity Positive Regulation Of DNA Helicase Activity Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Autophagosome Assembly Protein Folding Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Catalytic Activity Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Chaperone-mediated Protein Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Transport Along Microtubule Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464 24292274) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 32109421 31171785) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors and depression ( 27622933)	Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Idiopathic dilated cardiomyopathy ( 21459883) Left ventricular ejection fraction ( 32382064 32605384) Left ventricular end-systolic volume ( 32382064) Parkinson's disease ( 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	75 interacting genes: ACD ARRDC3 ATN1 ATXN7L2 BAIAP2L1 BCL2 CRYAB CTDSP1 CYSRT1 CYSTM1 DAZAP2 DNM2 DTX3 DVL1 DVL2 DYNLT1 EGR4 EYA2 FAM168B FAM189A2 FBXO7 FOXD4L1 GGN GLIS3 HELT HSPA1A HSPA5 HSPA8 HSPB1 HSPB2 HSPB2-C11orf52 HSPB7 HSPB8 INCA1 LENG8 LITAF LRRK1 LRRK2 MAGED1 MDFI MRPL38 NIBAN3 NOTO NR1H3 PDE9A PDLIM7 PIH1D2 PLA2G10 PLCG1 PLEKHB1 POT1 PRDM6 PRKAR1B PRR34 PTPN21 RUNX1 SF3B4 SHISA6 SIAH1 SPRY2 SRPK2 TBC1D3B TBC1D3G TINF2 TMEM174 TNK2 TP53BP2 TRIB3 TRIM27 TRIP6 TSC1 UNKL VPS37B WBP2 WNK1
Entrez ID		25913	9531
HPRD ID		07572	04860
Ensembl ID		ENSG00000128513	ENSG00000151929
Uniprot IDs		A0A024R739 A8MTK3 Q5MJ33 Q9NUX5	O95817
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7
Enriched GO Terms of Interacting Partners?
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