GAD2 and RDH10

Data Source:
BioGRID (two hybrid)

		GAD2	RDH10
Description		glutamate decarboxylase 2	retinol dehydrogenase 10
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding	Retinol Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP-retinol Dehydrogenase Activity
	Biological Process	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug	Retinoid Metabolic Process Metanephros Development In Utero Embryonic Development Retinoic Acid Biosynthetic Process Visual Perception Gonad Development Neural Crest Cell Development Embryonic Camera-type Eye Development Embryonic Forelimb Morphogenesis Retinol Metabolic Process Retinal Metabolic Process Ear Development Nose Development Embryonic Viscerocranium Morphogenesis Primary Lung Bud Formation Bud Elongation Involved In Lung Branching Positive Regulation Of Retinoic Acid Biosynthetic Process
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling	The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway
Drugs		Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Lean body mass ( 28552196)	Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Ceramide levels (C24:0) ( 32489964) Crohn's disease ( 22412388) Refractive error ( 32231278) Systolic blood pressure ( 30578418)
Interacting Genes		45 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BSND CACNG1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A GAD1 HIGD1C LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TMEM159 TNFRSF10D TSPAN33	4 interacting genes: ACSF2 DDA1 GAD2 RMDN2
Entrez ID		2572	157506
HPRD ID		11817	07605
Ensembl ID		ENSG00000136750	ENSG00000121039
Uniprot IDs		Q05329 Q5VZ30	A0A024R7X6 Q8IZV5
PDB IDs		1ES0 2OKK
Enriched GO Terms of Interacting Partners?
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