FUT4 and CR1

Data Source:
HPRD (in vivo)

		FUT4	CR1
Description		fucosyltransferase 4	complement C3b/C4b receptor 1 (Knops blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cell Surface Membrane Integral Component Of Membrane Golgi Cisterna Membrane Cell Periphery	Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Fucosyltransferase Activity 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity	Virus Receptor Activity Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Oligosaccharide Metabolic Process Fucosylation L-fucose Catabolic Process Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Neutrophil Degranulation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Cytolysis Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation ATP Export
Pathways		Lewis blood group biosynthesis	Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498) Small cell lung carcinoma ( 28604730)	Alzheimer's disease ( 21460840 19734903 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)
Interacting Genes		3 interacting genes: CR1 ITGB2 SELP	6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		2526	1378
HPRD ID		00083	00398
Ensembl ID		ENSG00000196371	ENSG00000203710
Uniprot IDs		P22083	E9PDY4 P17927
PDB IDs			1GKG 1GKN 1GOP 1PPQ 2MCY 2MCZ 2Q7Z 5FO9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?