FSHR and GRK4

Data Source:
HPRD (in vitro)

		FSHR	GRK4
Description		follicle stimulating hormone receptor	G protein-coupled receptor kinase 4
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Cytosol Cell Cortex Dendrite Neuronal Cell Body Photoreceptor Disc Membrane
	Molecular Function	Follicle-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity	G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus	G Protein-coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Receptor Internalization
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa
Diseases		Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Ovarian hyperstimulation syndrome (OHSS)
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Erectile dysfunction and prostate cancer treatment ( 20932654) Laterality in neovascular age-related macular degeneration ( 28775256) Lean body mass ( 28552196) Low density lipoprotein cholesterol levels ( 30498476) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Morning person ( 30696823) Plasma anti-thyroglobulin levels ( 29678681) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)	Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Mean platelet volume ( 32888494) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		20 interacting genes: AKT2 APPL1 ARR3 CANX CBX5 CGA FSHB GRK2 GRK4 GRK6 MT-RNR2 RPS27A S100A10 TOP1 TUG1 UBA52 UBB UBC YWHAQ ZBTB16	6 interacting genes: ADRB2 BDKRB2 CALM1 FSHR IKBKG NEDD4
Entrez ID		2492	2868
HPRD ID		00639	00656
Ensembl ID		ENSG00000170820	ENSG00000125388
Uniprot IDs		A0A1D5RMN4 P23945	P32298
PDB IDs		1XUN 1XWD 4AY9 4MQW	4YHJ
Enriched GO Terms of Interacting Partners?
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