PANX1 and FAXDC2

Data Source:
BioGRID (two hybrid)

		PANX1	FAXDC2
Description		pannexin 1	fatty acid hydroxylase domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein-containing Complex	Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Signaling Receptor Binding Structural Molecule Activity Calcium Channel Activity Protein Binding Wide Pore Channel Activity Leak Channel Activity Ion Channel Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding	C-4 Methylsterol Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Response To Ischemia Cation Transport Calcium Ion Transport Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Response To ATP Oogenesis Calcium Ion Transmembrane Transport	Positive Regulation Of Protein Phosphorylation Sterol Biosynthetic Process Positive Regulation Of Megakaryocyte Differentiation
Pathways		Electric Transmission Across Gap Junctions The NLRP3 inflammasome
Drugs		Probenecid
Diseases
GWAS		Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Autoimmune thyroid disease ( 32581359) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		16 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2	33 interacting genes: AQP6 ARL13B CD79A CGRRF1 CLDN7 CREB3L1 CYB5R3 EBP ELOVL4 ERGIC3 FCER1G FFAR2 GOLT1A GPR152 GPX8 HSD17B13 LMNA MGST3 NEMP1 PANX1 PGRMC2 RETREG3 SLC10A1 SLC10A6 SLC30A8 STOM STX4 TMEM106C TMEM139 TMEM31 TMEM86B TMPRSS2 TMX2
Entrez ID		24145	10826
HPRD ID		10526	12832
Ensembl ID		ENSG00000110218	ENSG00000170271
Uniprot IDs		A0A024R397 Q96RD7	Q96IV6
PDB IDs		6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN
Enriched GO Terms of Interacting Partners?
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