TMEFF2 and HTR4

Data Source:
BioGRID (two hybrid)

		TMEFF2	HTR4
Description		transmembrane protein with EGF like and two follistatin like domains 2	5-hydroxytryptamine receptor 4
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GO Annotations	Cellular Component	Basement Membrane Plasma Membrane Integral Component Of Membrane	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Molecular_function Protein Binding	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding
	Biological Process	Animal Organ Morphogenesis Tissue Development Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Wound Healing, Spreading Of Cells Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Stress Fiber Assembly	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Appetite
Pathways			Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diabetes (incident) ( 17903298) Sudden cardiac arrest ( 21658281)	Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)
Interacting Genes		10 interacting genes: DRD2 HSF2BP HTR4 NBPF19 NOTCH2NLA RIC3 TMEM237 TRHR UBIAD1 ZDHHC15	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		23671	3360
HPRD ID		05760	09074
Ensembl ID		ENSG00000144339	ENSG00000164270
Uniprot IDs		Q9UIK5	A0A2D3FAF9 Q13639
PDB IDs		2FMW	5EM9
Enriched GO Terms of Interacting Partners?
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