DAPK2 and MLC1

Data Source:
HPRD (in vitro)

		DAPK2	MLC1
Description		death associated protein kinase 2	modulator of VRAC current 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen Intracellular Membrane-bounded Organelle	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Integral Component Of Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs		Fostamatinib
Diseases			Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		Arterial stiffness index ( 31235810) Blood protein levels ( 28240269) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) HDL cholesterol levels ( 32203549) Platelet distribution width ( 27863252) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Acne (severe) ( 24927181) Body mass index (adult) ( 28430825)
Interacting Genes		6 interacting genes: APP CAMK2A CCDC91 FAM9B MLC1 TGFBR1	6 interacting genes: DAPK2 KDM1A MYLK PRMT6 ROCK1 TPT1
Entrez ID		23604	23209
HPRD ID		09905	05800
Ensembl ID		ENSG00000035664	ENSG00000100427
Uniprot IDs		A0A024R603 Q9UIK4	A0A024R4V4 Q15049
PDB IDs		1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW
Enriched GO Terms of Interacting Partners?
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