FOS and LMO3

Data Source:
BioGRID (two hybrid)

		FOS	LMO3
Description		Fos proto-oncogene, AP-1 transcription factor subunit	LIM domain only 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol Membrane Protein-DNA Complex Transcription Factor AP-1 Complex Neuron Projection	Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-containing Complex Binding R-SMAD Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Metal Ion Binding
	Biological Process	Conditioned Taste Aversion DNA Methylation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Light Stimulus Response To Gravity Response To Toxic Substance Cytokine-mediated Signaling Pathway Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Cellular Response To Reactive Oxygen Species Response To Immobilization Stress Skeletal Muscle Cell Differentiation Response To Muscle Stretch Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Positive Regulation Of Neuron Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Pseudoephedrine Nadroparin
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)	Chronotype ( 30696823) Household income (MTAG) ( 31844048) Tourette syndrome ( 30818990) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		121 interacting genes: AKAP5 ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5ME BATF BCL3 CABP1 CARM1 CCDC120 CCND1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 DNMT3L EEF1D ELK1 ELK4 ENKD1 EPHB2 ETS1 ETS2 FHL3 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HNF1A HSPA1A JUN JUNB JUND KDM2A KDM2B LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK3 MAPK7 MDM2 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PIN1 PML POLR2E PRKAA2 PRKACA PRKAR2A PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TENT5B TP53 TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133	122 interacting genes: ABI2 AIMP2 AMIGO1 AMOTL2 AVPI1 BANP BCAS2 BEND5 BEND7 BHLHE40 BLZF1 C19orf54 CARD9 CARF CBY2 CCDC33 CCDC85B CCSER1 CDYL2 CEP170P1 CEP57 CEP57L1 CYSRT1 DCDC2 DVL2 FAM131C FBLIM1 FOS GABPB1 GMEB2 GOLGA2 GOLGA6L9 GPATCH2L HMBOX1 HNRNPC HNRNPH1 HNRNPM HOMEZ HSPB2 HSPB2-C11orf52 IKZF1 IL16 INCA1 KANK2 KCTD1 KIF2A KRBOX4 KRT31 KRT38 KXD1 LDB1 LDB2 LIMS1 LNPK LPXN LZTS1 LZTS2 MAD1L1 MALSU1 MBD3 MBD3L1 MBIP MDFI MEIS3 MID2 MTUS2 MYOG MYOZ3 NBPF22P NDOR1 NFKBID NHLH2 NIF3L1 NTAQ1 NUTM1 PELO PHC2 PICK1 PNMA1 POU6F2 PPP1R13B PXN QRICH1 RALYL RCN1 RFC5 RFX6 RORA SAMD3 SH2B2 SHISA6 SLAIN1 SP4 TAX1BP1 TCP10L TEPSIN THAP1 TMEM121 TRAPPC2L TRIB3 TRIM23 TRIM54 TUFT1 USP54 VBP1 VMAC VPS28 WASHC1 WWOX ZBTB43 ZBTB8A ZBTB8B ZIM3 ZNF143 ZNF526 ZNF587 ZNF620 ZNF641 ZNF69 ZNF84 ZRANB1 ZSCAN9
Entrez ID		2353	55885
HPRD ID		01275	11832
Ensembl ID		ENSG00000170345	ENSG00000048540
Uniprot IDs		P01100 Q6FG41	A0A024RAT1 Q8TAP4 Q9NYC6
PDB IDs		1A02 1FOS 1S9K
Enriched GO Terms of Interacting Partners?
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