ZFYVE26 and TDO2

Data Source:
BioGRID (two hybrid)

		ZFYVE26	TDO2
Description		zinc finger FYVE-type containing 26	tryptophan 2,3-dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Centrosome Midbody	Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Double-strand Break Repair Via Homologous Recombination Regulation Of Cytokinesis	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin
Pathways			Tryptophan catabolism
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 31959851) Asthma (childhood onset) ( 31036433)	Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)
Interacting Genes		35 interacting genes: ALAS1 ASB15 CBY2 CCDC125 CCDC136 CEP44 GOLGA2 GPRASP2 HMBOX1 HNRNPC HOOK2 KRT15 KRT27 KRT34 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MAGED1 MDFI PLEKHF2 PNMA1 PNMA5 PPP1R16A PRDM6 SPAG5 SSX2IP TADA2A TCEANC TDO2 TFIP11 TRAF1 TTC23 USHBP1 USP20	20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26
Entrez ID		23503	6999
HPRD ID		15734	01847
Ensembl ID		ENSG00000072121	ENSG00000151790
Uniprot IDs		Q68DK2	P48775
PDB IDs			4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6VBN
Enriched GO Terms of Interacting Partners?
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