SIRT3 and PYCR1

Data Source:
BioGRID (pull down)

		SIRT3	PYCR1
Description		sirtuin 3	pyrroline-5-carboxylate reductase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Enzyme Binding NAD-dependent Protein Deacetylase Activity Sequence-specific DNA Binding NAD+ Binding	Pyrroline-5-carboxylate Reductase Activity Protein Binding Identical Protein Binding
	Biological Process	Protein ADP-ribosylation Protein Deacetylation Mitochondrion Organization Aging Aerobic Respiration Histone Deacetylation Positive Regulation Of Insulin Secretion Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Proline Biosynthetic Process Cellular Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation	Glutamate and glutamine metabolism
Drugs		Adenosine-5-Diphosphoribose	NADH Proline
Diseases			Geroderma osteodysplasticum
GWAS		Coronary artery disease ( 33020668) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)
Interacting Genes		8 interacting genes: ALDH2 DNM1L H3C1 MDM2 PDP1 PEX5 PYCR1 XRCC6	6 interacting genes: BNIPL CDK2AP2 HNRNPD NUDT21 SIRT3 TNPO2
Entrez ID		23410	5831
HPRD ID		06836	01528
Ensembl ID		ENSG00000142082	ENSG00000183010
Uniprot IDs		Q9NTG7	A0A024R8U9 E2QRB3 J3QL32 P32322 Q8TBX0
PDB IDs		3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO	2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3
Enriched GO Terms of Interacting Partners?
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